Ancient pathways promoting unicellularity and multicellularity are associated with cancer, the former being pro‐oncogenic and the latter acting to suppress oncogenesis. However, there are only a limited number of non‐vertebrate models for studying these pathways. Here, we review Dictyostelium discoideum and describe how it can be used to understand these gene networks. D. discoideum has a unicellular and multicellular life cycle, making it possible to study orthologs of cancer‐associated genes in both phases. During development, differentiated amoebae form a fruiting body (...) composed of a mass of spores that are supported atop a stalk. A portion of the cells sacrifice themselves to become non‐reproductive stalk cells. Cheating disrupts the principles of multicellularity, as cheater cells alter their cell fate to preferentially become spores. Importantly, D. discoideum has gene networks and several strategies for maintaining multicellularity. Therefore, D. discoideum can help us better understand how conserved genes and pathways involved in multicellularity also influence cancer development, potentially identifying new therapeutic avenues. (shrink)

This book is a small handbook designed to give Institutional Review Board (IRB) members the information they need to protect the rights and welfare of research subjects in a way that is both effective and efficient. The chapters of this book are short and to the point. Topic-specific chapters list the criteria IRB members should use to determine how to vote on specific kinds of studies and offer practical advice on what IRB members should do before and during full-committee meetings.

This is a comprehensive review of the psychological literature on wisdom by leading experts in the field. It covers the philosophical and sociocultural foundations of wisdom, and showcases the measurement and teaching of wisdom. The connection of wisdom to intelligence and personality is explained alongside its relationship with morality and ethics. It also explores the neurobiology of wisdom, its significance in medical decision-making, and wise leadership. How to develop wisdom is discussed and practical information is given about how to instil (...) it in others. The book is accessible to a wide readership and includes virtually all of the major theories of wisdom, as well as the full range of research on wisdom as it is understood today. It takes both a basic-science and applied focus, making it useful to those seeking to understand wisdom scientifically, and to those who wish to apply their understanding of wisdom to their own work. (shrink)

I formulate a counterfactual version of the notorious ‘Ramsey Test’. Whereas the Ramsey Test for indicative conditionals links credence in indicatives to conditional credences, the counterfactual version links credence in counterfactuals to expected conditional chance. I outline two forms: a Ramsey Identity on which the probability of the conditional should be identical to the corresponding conditional probability/expectation of chance; and a Ramsey Bound on which credence in the conditional should never exceed the latter. Even in the weaker, bound, form, the (...) counterfactual Ramsey Test makes counterfactuals subject to the very argument that Lewis used to argue against the indicative version of the Ramsey Test. I compare the assumptions needed to run each, pointing to assumptions about the time‐evolution of chances that can replace the appeal to Bayesian assumptions about credence update in motivating the assumptions of the argument. I finish by outlining two reactions to the discussion: to indicativize the debate on counterfactuals; or to counterfactualize the debate on indicatives. (shrink)

Several scholars and many religiously conservative thinkers have recently charged that Hitler’s ideas about race and racial struggle derived from the theories of Charles Darwin (1809-1882), either directly or through intermediate sources. So, for example, the historian Richard Weikart, in his book From Darwin to Hitler , maintains: “No matter how crooked the road was from Darwin to Hitler, clearly Darwinism and eugenics smoothed the path for Nazi ideology, especially for the Nazi stress on expansion, war, racial struggle, and racial (...) extermination.” In a subsequent book, Hitler’s Ethic: The Nazi Pursuit of Evolutionary Progress, Weikart argues that Darwin’s “evolutionary ethics drove him [Hitler] to engage in behavior that the rest of us consider abominable.” Other critics have also attempted to forge a strong link between Darwin’s theory and Hitler’s biological notions. In the 2008 film “Expelled,” a documentary defense of Intelligent Design, the Princeton trained philosopher David Berlinski, in conversation with Weikart, confidently asserts: “If you open Mein Kampf and read it, especially if you can read it in German, the correspondence between Darwinian ideas and Nazi ideas just leaps from the page.” John Gray, former professor at the London School of Economics, does allow that Hitler’s Darwinism was “vulgar.” Hannah Arendt also appears to have endorsed the connection when she declared: “Underlying the Nazis’ belief in race laws as the expression of the law of nature in man, is Darwin’s idea of man as the product of a natural development which does not necessarily stop with the present species of human being.” Put “Darwin” and “Hitler” in a search engine and several million hits will be returned, most from religiously and politically conservative websites, articles, and books. (shrink)

The eminent historian and philosopher of biology, Michael Ruse, has written several books that explore the relationship of evolutionary theory to its larger scientific and cultural setting. Among the questions he has investigated are: Is evolution progressive? What is its epistemological status? Most recently, in "Darwin and Design: Does Evolution have a Purpose?," Ruse has provided a history of the concept of teleology in biological thinking, especially in evolutionary theorizing. In his book, he moves quickly from Plato and Aristotle to (...) Kant and such British thinkers as Paley and Whewell. His main focus, though, is on Darwin's theory and its subsequent fate. Ruse rests his history on some shaky historical and philosophic assumptions, particularly the unexamined notion that evolutionary theory is an abstract entity that is unproblematically realized in different historical periods. He also assumes that Darwin conceived nature as if it were a Manchester spinning loom -- a clanking, dispassionate machine. A more subtle analysis, which Ruse eschews, might discover that Darwin's conception of nature owed a strong debt to German Romanticism and that he contrived to infuse nature with moral and aesthetic values, not to suck them from nature. Ruse proves he is a thinker to contend with, and this essay is quite contentious. (shrink)

The goal of this paper is two-fold: first, to emphasize causality in disease ontology and knowledge representation, presenting a general and cursory discussion of causality and causal chains; and second, to clarify and develop the River Flow Model of Diseases (RFM). The RFM is an ontological account of disease, representing the causal structure of pathology. It applies general knowledge of causality using the concept of causal chains. The river analogy of disease is explained, formal descriptions are offered, and the RFM (...) disease definition is refined by describing causal chains in terms of causal relations. The definition is updated to coincide with the actual RFM classes found in its upper-level ontology, YAMATO, which brings to light some challenges in developing both YAMATO and the RFM. The RFM is also discussed in relation to another ontological account of disease. Strategies are offered toward interoperability between these theories. (shrink)

This collection of 21 essays explores the creative interaction among the cognitive neurosciences, philosophy, and theology. It is the result of an international research conference co-sponsored by the Vatican Observatory, Rome, and the Center for Theology and the Natural Sciences, Berkeley.

History of science and philosophy of science are not perfectly complementary disciplines. Several important asymmetries govern their relationship. These asymmetries, concerning levels of analysis, evidence, theories, writing, and training show that to be a decent philosopher of science is more difficult than being a decent historian. But to be a good historian-well, the degree of difficulty is reversed.

Thomas S. Kuhn’s The Structure of Scientific Revolutions was a watershed event when it was published in 1962, upending the previous understanding of science as a slow, logical accumulation of facts and introducing, with the concept of the “paradigm shift,” social and psychological considerations into the heart of the scientific process. More than fifty years after its publication, Kuhn’s work continues to influence thinkers in a wide range of fields, including scientists, historians, and sociologists. It is clear that The Structure (...) of Scientific Revolutions itself marks no less of a paradigm shift than those it describes. In Kuhn’s “Structure of Scientific Revolutions” at Fifty, leading social scientists and philosophers explore the origins of Kuhn’s masterwork and its legacy fifty years on. These essays exhume important historical context for Kuhn’s work, critically analyzing its foundations in twentieth-century science, politics, and Kuhn’s own intellectual biography: his experiences as a physics graduate student, his close relationship with psychologists before and after the publication of Structure, and the Cold War framework of terms such as “world view” and “paradigm.”. (shrink)

Just before Ernst Haeckel’s death in 1919, historians began piling on the faggots for a splendid auto-da-fé. Though more people prior to the Great War learned of Darwin’s theory through his efforts than through any other source, including Darwin himself, Haeckel has been accused of not preaching orthodox Darwinian doctrine. In 1916, E. S. Russell, judged Haeckel's principal theoretical work, Generelle Morphologie der Organismen, as "representative not so much of Darwinian as of pre-Darwinian thought."1 Both Stephen Jay Gould and Peter (...) Bowler endorse this evaluation, and see as an index of Haeckel’s heterodox deviation his use of the biogenetic law that ontogeny recapitulates phylogeny.2 Michael Ruse, without much analysis, simply proclaims that “Haeckel and friends were not true Darwinians.”3 These historians locate the problem in Haeckel’s inclinations toward Naturphilosophie and in his adoption of the kind of Romantic attitudes characterizing the earlier biology of Goethe. These charges of heresy assume, of course, that Darwin’s own theory harbors no taint of Romanticism and that it consequently remains innocent of the doctrine of recapitulation. I think both assumptions quite. (shrink)

Our image of Darwin is hardly that of a German metaphysician. By reason of his intellectual tradition—that of British empiricism—and psychological disposition, he was a man of apparently more stolid character, one who could be excited by beetles and earthworms but not, we assume, by abstruse philosophy. Yet Darwin constructed a theory of evolution whose conceptual grammar expresses and depends on a certain kind of metaphysics. During his youthful period as a romantic adventurer, he sailed to exotic lands and returned (...) to construct a theory that attacked the citadels of orthodoxy. In the long process of theory construction, he explored difficult philosophical questions—for instance, the nature of reason and the mind-body problem. Moreover, he founded that theory.. (shrink)

The risk of stroke for a child with SCD is many times greater than that of a healthy child without SCD or heart disease. There is a technique that allows the identification of the children with SCD who have high risk even within this relatively high-risk group. And there is a highly effective preventive treatment. While this would on the surface appear to be a straightforward medical decision, it is not. One must weigh the benefits of preventing permanent brain damage (...) against the risks of infection from transfused blood, iron overload, which is the result of the frequent transfusions, and rare transfusion reactions. (shrink)

Sickle cell anemia is a disease characterized by abnormal hemoglobin structure. There is a mutation in the beta-globin gene that changes the sixth amino acid from glutamic acid to valine causing the mutated hemoglobin to polymerize reversibly when deoxygenated to form a gelatinous network of fibrous polymers that stiffen and distort the red blood cell membrane. This leads to episodes of microvascular vasoocclusion and premature RBC destruction leading to hemolytic anemia. For reasons that are unclear, some children develop a large (...) artery vasculopathy involving the intracranial arteries supplying the brain.The risk of stroke for a child with SCD is many times greater than that of a healthy child without SCD or heart disease. There is a technique that allows the identification of the children with SCD who have high risk even within this relatively high-risk group. And there is a highly effective preventive treatment. (shrink)

We cannot understand contemporary psychology without first researching its history. Unlike other books on the history of psychology, which are chronologically ordered, this Handbook is organized topically. It covers the history of ideas in multiple areas of the field and reviews the intellectual history behind the major topics of investigation. The evolution of psychological ideas is described alongside an analysis of their surrounding context. Readers learn how eminent psychologists draw on the context of their time and place for ideas and (...) practices, and also how innovation in psychology is an ongoing dialogue between past, present, and anticipated future. (shrink)

Our image of Herbert Spencer is that of a bald, dyspeptic bachelor, spending his days in rooming houses, and fussing about government interference with individual liberties. Beatrice Webb, who knew him as a girl and young woman recalls for us just this picture. In her diary for January 4, 1885, she writes: Royal Academy private view with Herbert Spencer. His criticisms on art dreary, all bound down by the “possible” if not probable. That poor old man would miss me on (...) the whole more than any other mortal. Has real anxiety for my welfare—physical and mental. Told him story of my stopping cart horse in Hyde Park and policeman refusing to come off his beat to hold it. Want of public spirit in passers-by not stopping it before. “Yes, that is another instance of my first principle of government. Directly you get state intervention you cease to have public spirit in individuals; that will be a constantly increasing tendency and the State, like the policeman, will be so bound by red-tape rules that it will frequently leave undone the simplest duties.”1 Spencer appears a man whose strangled emotions would yet cling to a woman whose philosophy would be completely alien to his own, as Webb’s Fabian Socialism turned out to be. Our image of Darwin is more complex than our image of Spencer. We might think of him nestled in the bosom of his large family, kindly, and just a little sad. The photo of him taken by Julia Cameron reveals the visage of an Old Testament prophet, though one, not fearsome, but made wise by contemplating the struggle of life on this earth. These images have deeply colored our reaction to the ideas of each thinker. The pictures are not false, but they are cropped portraits that tend to distort our reactions to the theories of each. If we examine the major features of their respective. (shrink)

This is a much-needed development from the first edition that provides an update on the theory and research on love by world-renowned scientific experts. It explores love from a diverse range of standpoints: social-psychological, evolutionary, neuropsychological, clinical, cultural, and even political. It considers questions such as: how men and women differ in their love, what makes us susceptible to jealousy and envy in relationships, how love differs across various cultures? As the neuropsychological basis of love is examined, this study showcases (...) what attracts people to one another, why love has developed the way it has over time, and what evolutionary purpose it serves. It also analyses why and when love relationships both succeed and fail, which means readers will be rewarded with a better understanding of their own relationships and those of others, as well as what can be done to build a lasting, loving relationship. (shrink)

After almost a decade, the discussion initiated by Professor Edmund Gettier's provocative paper “Is Justified True Belief Knowledge?” continues. The most recent contribution to this discussion is Professor John Turk Saunders' attempt to counter Professor Irving Thalberg's claim that a principle that Gettier employs in reaching his notorious negative conclusion is unjustified. I am moved to add to the discussion at this time because it seems to me that the principle in question is unjustified. But more fundamentally, Gettier's argument fails (...) because the putative counter-examples on which it rests fail to make their intended point. I shall discuss these claims in turn.The epistemic principle which I consider unjustified is the one which Thalberg has called the Principle of Deducibility for Justification and which Gettier formulates as follows: “for any proposition P, if S is justified in believing P, and P entails Q, and S deduces Q from P and accepts Q as a result of this deduction, then S is justified in believing Q.”. (shrink)

If religion means a commitment to a set of theological propositions regarding the nature of God, the soul, and an afterlife, Ernst Haeckel (1834-1919) was never a religious enthusiast. The influence of the great religious thinker Friedrich Daniel Schleiermacher (1768-1834) on his family kept religious observance decorous and commitment vague.2 The theologian had maintained that true religion lay deep in the heart, where the inner person experienced a feeling of absolute dependence. Dogmatic tenets, he argued, served merely as inadequate symbols (...) of this fundamental experience. Religious feeling, according to Schleiermacher’s Über die Religion (On religion, 1799), might best be cultivated by seeking after truth, experiencing beauty, and contemplating nature.3 Haeckel practiced this kind of Schleiermachian religion all of his life. Haeckel’s association with the Evangelical Church, even as a youth, had been conventional. The death of his first wife severed the loose threads still holding him to formal observance. The power of that death, his obsession with a life that might have been, and the dark feeling of love forever lost drove him to find a more enduring and rational sub-. (shrink)

Chapter III contains several puzzles and unexpected features. The first puzzle regards the chapter’s relationship to Chapter IV: Natural Selection. Both chapters treat of natural selection, so what distinguishes them? Is it that Chapter IV indicates the intelligence behind nature’s selections and Chapter III introduces the analog of intelligence? And is it that Chapter III suggests that natural selection performs an eliminative function, while Chapter IV shows the positive impact of selection? In Chapter IV, and in many subsequent chapters, natural (...) selection, Darwin says, operates only for the good of each individual creature, though Chapter III suggests it destroys most individuals. Darwin asserts that he uses the term “struggle” metaphorically, which raises the question of the explanatory weight his metaphors carry, such metaphors as "the face of nature.” There are a number of unexpected features of Darwin’s analysis displayed in the chapter: for example, his introduction of a new concept of the selective environment and the several experiments he performs to establish his theory, e.g., from mathematical and thought experiments to controlled empirical experiments. Chapter III is a rich though puzzling chapter. (shrink)

The ethics of artificial intelligence (AI) is a research topic with both theoretical and practical significance. However, the ethical and moral aspects of conceptual, ontological, semantic, and knowledge modeling, more specifically, and which are sometimes found in AI applications, is not being given sufficient attention. I argue that it should. Whether considering using or developing these meaning-focused models, there are ethical aspects. This paper offers a preliminary outline about this potentially new research field, discussing: some questions and areas of concern, (...) their significance; scenarios of ethical import, and initial ethical guidelines. A focus area, potential case study, and lens through which to see the ethical significance at hand, is ontologies, with emphasis on the most abstract ontologies (so-called generic, foundational, top-level or upper ontologies). This would aim to show the ethical import of highly abstract (often philosophical) ontological choices, assumptions, and their effects on data, developers, users, and society. In particular, I stress the need for critical examination of such models, their content, their intended meanings, assumptions, ideologies, as well as the development process. Both the ethics of, and ethics in, these activities are, therefore, of interest. Topics in the ethics of AI that are relevant include: transparency, bias, data-sharing, privacy, control over data, etc. This paper thereby contributes to the ethics of AI, as well as the ethics of information, of knowledge managment and relevant topics by developing and discussing the ethics of ontology (and similar systems). Future development will refine and add to the ideas expressed in this paper. (shrink)

Ernst Haeckel’s popular book Nat¨urliche Sch¨opfungs- geschichte (Natural history of creation, 1868) represents human species in a hierarchy, from lowest (Papuan and Hottentot) to highest (Caucasian, including the Indo-German and Semitic races). His stem-tree (see Figure 1) of human descent and the racial theories that accompany it have been the focus of several recent books—histories arguing that Haeckel had a unique position in the rise of Nazi biology during the first part of the 20th century. In 1971, Daniel Gasman brought (...) the initial bill of particulars; he portrayed Haeckel as having specific responsibility for Nazi racial programs. He argued that Darwin’s champion had a distinctive authority at the end of the 19th century, throwing into the shadows the myriads of others with similar racial attitudes.1 But it was not simply a general racism that Haeckel expressed; he was, according to Gasman (1971: 157–159), a virulent anti-Semite. Since its original publication, Gasman’s thesis has caught on with a large number of historians, so that in the present period it is usually taken as a truism, an obvious fact of the sordid history of biological thought in the first half of the 20th century.2 Perhaps the most prominent scholar—at least among historians of biology—to adopt and advance Gasman’s contention was Stephen Jay Gould. In his first book, Ontogeny and Phy- logeny (1977), Gould took as his subject Haeckel’s principle of recapitulation, the proposal that during ontogeny the developing embryo went through the same morphological stages as the phylum passed through in its evolutionary descent. So according to this conception, the human embryo begins as a one-celled creature, then takes on the form of an ancient invertebrate (e.g., a gastraea), then of a primitive vertebrate, then of an early mammal, then of a primate, and finally of a distinct.. (shrink)

In “A Defense of Presentism ”, Ned Markosian addresses the problem of singular propositions about non-present objects. The proposed solution uses a paraphrasing strategy that differentiates between two kinds of meaning in declarative sentences, and also distinguishes between two truth-conditions for singular propositions. The solution, however, is unsatisfactory. I demonstrate that the both truth-conditions suffer from the same problems in spite of the examples used to support the claim that one is a proper treatment for singular propositions. Part of the (...) difficulty is in the limited expressivity of logical formalisms, a limitation not unique to the philosophy of time, but which calls for greater attention. (shrink)

Darwin's theory of natural selection and its moral purpose -- Appendix 1: the logic of Darwin's long argument -- Appendix 2: the historical ontology and location of scientific theories -- Darwin's principle of divergence: why Fodor was almost right -- Darwin's romantic quest: mind, morals, and emotions -- Appendix: assessment of Darwin's moral theory -- The relation of Spencer's evolutionary theory to Darwin's -- Ernst Haeckel's scientific and artistic struggles -- Haeckel's embryos: fraud not proven -- The linguistic creation of (...) man: August Schleicher and the missing link in Darwinian theory -- Was Hitler a Darwinian? (shrink)

By studying Lucretius’ poem De Rerum Nature and its impact on literary and political circles in Machiavelli’s Florence, this book examines the way that the Lucretian concepts served Machiavelli as revolutionary new materials for the creation of his infamously brutal political science.

Though not the first to use the term "psychology" (psychologia), ' Christian Wolff did give it currency in the mid-eighteenth century. He was the first to mark off the discipline of empirical psychology and to distinguish it from rational, or theoretical, psychology. This distinction and his conception of the two corresponding methods of conducting psychological inquiry, especially his emphasis on the use of introspection, profoundly inffuenced the course of psychological..

Scholars have usually given Darwin’s theory a neo-Darwinian interpretation. A more careful examination of the language of Darwin’s notebooks and the language of the Origin of Species indicates that he reconstructed nature with a definite purpose: the final goal of man as a moral creature. In the aftermath of the Origin, Darwin, however, became more circumspect.

Through the last half of the nineteenth century and the first part of the twentieth, no scientist more vigorously defended Darwinian theory than the German Ernst Haeckel (1834–1919). More people learned of the new ideas through his voluminous publications, translated into numerous languages, than through any other source, including Darwin’s own writings. He enraged many of his contemporaries, especially among the religiously orthodox; and the enmity between evolutionary theory and religious fundamentalism that still burns brightly today may in large measure (...) be attributed to Haeckel’s unremitting attacks on the ingressions of religion into science. Though he retained a life-long friendship with and the support of Darwin, some in the scientific community who were critical of evolutionary theory—Emil Du Bois-Reymond, Rudolf Virchow, and Louis Agassiz, for instance—accused him of deception. That charge has been renewed in our time based on seemingly incontrovertible evidence. In a Science magazine article published in 1997, ‘‘Haeckel’s Embryos: Fraud Rediscovered,’’ Haeckel, was indicted of having intentionally misrepresented embryological development (Pennisi 1997). The article reported that the work of Michael Richardson and his colleagues demonstrated this malfeasance through a comparison of Haeckel’s illustrations of early-stage embryos with photographs of the same species at a comparable stage (see Fig. 1). The photos showed embryos of various species that differed among themselves and certainly from Haeckel’s images. The differences were striking and the implication obvious: fraudulent misrepresentation. Richardson, as quoted in the article, affirmed the charge: ‘‘It looks like it’s turning out to be one of the most famous fakes in biology’’. (shrink)

In this paper I argue for the following three claims. (1) the teleological argument is much weaker than plantinga allows, And, Indeed, As plantinga formulates it, It does not seem even to support a theistic position. (2) the argument from evil is much stronger than plantinga maintains, And, In any case, His attempt to show that it is without logical force is unsuccessful. (3) the analogical argument for other minds is indeed not strong, But it is not the best argument (...) we have. (edited). (shrink)